Figure 1: A flow-microreactor system.
From: A flow-microreactor approach to protecting-group-free synthesis using organolithium compounds
(a) A schematic diagram of the system. 2-Bromo-1,3,5-trimethylbenzene (mesityl bromide, MesBr) was reacted with n-butyllithium using T-shaped micromixer M1 and microtube reactor R1 at 0 °C. The resulting mesityllithium solution was reacted with an acyliodobenzene in T-shaped micromixer M2 and microtube reactor R2 at −70 °C. The resulting short-lived acylphenyllithium species was trapped with an electrophile using T-shaped micromixer M3 and microtube reactor R3 at −70 °C. (b) An integrated device in which M2 (inner diameter: 250 μm), R2 (inner diameter: 250 μm, length: 1.0 cm) and M3 (inner diameter: 250 μm) are combined.
