Figure 3: Protein module connectivity and correlation with size traits.

(a) Higher-order clustering of protein modules. The modules were hierarchically clustered based on Spearman correlation (|ρ|) between the principal components of the individual modules. Functionalities enriched for the higher-order module clusters are shown. The significance for the enrichment was determined (<0.05) by Benjamin–Hochberg method. (b) Relationship between module correlations with absolute CS and IOD. Spearman’s correlation between the principal components of the modules and size traits are plotted. The fitted line and the r2 from linear regression are shown. (c) Relationship between module correlations with absolute and relative CSs.