Figure 2: Structures of MfPC holoenzyme.
From: A distinct holoenzyme organization for two-subunit pyruvate carboxylase
(a) Schematic drawing of the mutant MfPC α2β4 holoenzyme structure, having the shape of the letter U in this view. The domains are coloured according to Fig. 1a, except the BC domain of the second α subunit is coloured in pink. BT-L, BT-like domain. (b) Structure of the mutant MfPC holoenzyme viewed down the BC domain dimer, along the arrow of a. (c) Structure of wild-type MfPC holoenzyme, having the shape of a butterfly in this view. (d) Structure of the wild-type MfPC holoenzyme viewed down the BC domain dimer, along the arrow of c. The two distal β subunits (β2 and β4) are splayed away from each other, and other differences to the mutant MfPC holoenzyme are also clearly visible by comparing with b.
