Figure 3: Block of KAR currents by the GluK2/GluK5 antagonist UBP310. | Nature Communications

Figure 3: Block of KAR currents by the GluK2/GluK5 antagonist UBP310.

From: Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells

Figure 3

(a) Sample traces illustrating KAR currents evoked by glutamate uncaging on TEs of CA3 PCs in organotypic slice cultures prepared from GluK2+/+ and GluK2−/− not transfected (NT) or transfected with 3 ng μl−1 of GluK2a cDNA or 80 ng μl−1 in the absence or presence of UBP 310 (3 μM). (b) Bar graph summarizing the percentage of inhibition of UBP 310 (3 μM) on the KAR currents evoked by glutamate uncaging. In GluK2+/+ NT: n=6 cells; 3 ng μl−1: n=7 cells; 3 ng μl−1: n=12 cells; 7 mice. Values are presented as mean ±s.e.m. of n experiments. Data were compared using one-way analysis of variance followed by Dunnett’s multiple comparison test (NS, not significant; P>0.05 and **P<0.01).

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