Figure 7: TMEM219 plays a critical role in lung melanoma metastasis.
From: IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses
TMEM219 null (−/−) mice and WT (+/+) mice were challenged with B16-F10 melanoma cells and lung metastasis was evaluated. (a) Representative photograph of lungs from WT and TMEM219 null mice 2 weeks after challenge with B16-F10 melanoma cells. (b) The number of pleural melanoma colonies in lungs from melanoma-challenged WT and TMEM219 null mice. (c,d) The levels of total and active TGF-β1 in BAL fluids from WT mice and TMEM219−/− mice. (a) Representative photograph of lungs from an experiment with a minimum of five mice per group. The values in the remaining panels represent the means±s.e.m. of evaluations in a minimum of four mice. *P<0.05; **P<0.01 by Student's t-test.
