Figure 5: Association between rs641738 genotype and inflammatory, oxidative stress and macrophage activation markers.

rs641738 genotype correlation with MDA, an oxidative stress marker (a), IL-6 (b) and TNF-α, as inflammatory markers (c). Clinical and anthropometric characteristics of these patients are shown in Supplementary Table 8 (n=95). The x axis shows the genotypes at rs641738 using the dominant model of inheritance (CC=27 and CT/TT=68) and the y axis shows serum MDA as ng ml⁻¹ (a), IL-6 as pg ml⁻¹, TNF-α as pg ml⁻¹. (d) Association between MBOAT7 rs641738 genotype and the macrophage activation marker sCD163 (n=510). The x axis shows the genotypes at rs641738 using the dominant model of inheritance (CC=178 and CT/TT=332) and the y axis shows sCD163 as mg ml⁻¹. The number of independent samples tested in each group is shown in parentheses. Each group is shown as a box plot and the median values are shown as thick dark horizontal lines. The box covers the twenty-fifth to seventy-fifth percentiles. We tested the difference in the median values among genotypes using the two-tailed Mann–Whitney test. We plotted the box plots using Graphpad prism 5.