Table 1 Genome-wide significant association of 6q25.3 with acute otitis media.

From: Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene

SNP

Chr

Pos (hg19)

Gene

A1/A2

MAF cases/controls

Stage

OR CHOP (95% CI)

P CHOP

OR GenR (95% CI)

P GenR

P meta

rs2932989

6

159699284

FNDC1

T/G

0.17/0.13

Discovery

1.41 (1.23, 1.62)

1.46e−06

1.25 (1.05, 1.48)

1.02e−02

4.36e−08*

      

Replication

1.35 (1.05, 1.73)

1.55e−02

   
      

Combined

    

2.15e−09†

  1. A1, minor allele; A2, major allele; Chr, chromosome; CI, confidence interval; MAF, minor allele frequency; OR, odds ratio; P, P value; Pos, position; SNP, single-nucleotide polymorphism.
  2. *P value of meta-analysis at discovery stage.
  3. †P value of meta-analysis of all cohorts.
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