Figure 4: Structure activity relationship of adamantane compounds. | Nature Communications

Figure 4: Structure activity relationship of adamantane compounds.

From: KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

Figure 4

(a) Inhibitory effect of different AC derivatives (10 μM) on Kv7.1/KCNE1 channels. Chemical modifications at both ends of AC-1 were investigated as indicated. Inhibition was determined as percent change in current amplitude at the end of a depolarizing test pulse to +40 mV (n=3–5, ±s.e.m.). (b) Lack of correlation between inhibitory effect and hydrophobicity of AC compounds (n=3–5, ±s.e.m.). (c) Lack of correlation between inhibitory effect and volume of AC derivatives (n=3–5, ±s.e.m.). miLog P values and volume were calculated using Property Calculator (Molinspiration Cheminformatics).

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