Figure 7: Single point mutagenesis of the transmembrane region of KCNE1. | Nature Communications

Figure 7: Single point mutagenesis of the transmembrane region of KCNE1.

From: KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

Figure 7

(a) Location of the transmembrane region of KCNE1 (KCNE1-TM) in a Kv7.1/KCNE1 channel complex. (b) Inhibition of Kv7.1/KCNE1 channel complexes by 300 nM AC-1. Single point mutations were introduced as indicated and inhibition was determined as percent change in current amplitude at the end of a depolarizing test pulse to +40 mV (n=3–5, ±s.e.m.; one-way analysis of variance, Dunnet’s post hoc test; ***P<0.001).

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