Table 1 ASE of imprinted genes in cardiovascular tissues.

From: Loss of RNA expression and allele-specific expression associated with congenital heart disease

Gene

Chr:Pos (hg19)

CHD ASE *

GTEx ASE *

% ASE

Coding/ noncoding

Expressed allele

FHE

Mouse

ZDBF2

chr2:207139522-207179148

4/7

15/15

86

C

P

8.2

ASE†

NAP1L5

chr4:89617065-89619023

9/10

14/14

96

C

P

18.3

NE

FAM50B

chr6:3849631-3851551

4/5

22/23

93

C

P

37.9

NE

PLAGL1

chr6:144261436-144385735

16/16

33/34

98

C

P

39.7

ASE

PEG10

chr7:94285636-94299006

1/1‡

0/0

100

C

P

98.8

ASE

MEST

chr7:130126015-130146138

7/8

1/1

89

C

P

47.7

ASE

H19

IGF2

chr11:2016405-2170833chr11:2016405-2170833

12/12

4/4

68/69

1/1

99

100

NC

C

M

P

3287

2677

ASE

ASE

DLK1

MEG3

RTL1

chr14:101193201-101373305chr14:101193201-101373305chr14:

101193201-101373305

17/17

5/5

1/1‡

39/40

2/8

0/0

98

54

100

C

NC

C

P

M

M

76.4

285.3

3.2

ASE

ASE

ASE†

MAGEL2

NDN

SNRPN

SNURF

chr15:23888695-25244225chr15:23888695-25244225chr15:23888695

-25244225chr15:23888695-25244225

2/2

55/55

60/60

0/0

0/0

NS

48/48

4/4

100

100

100

100

C

C

C

C

P

P

P

P

3.9

63.8

68.9

99.1

ASE†§

ASE

ASE

ASE

PEG3

chr19:57321444-57352094

14/15

14/17

88

C

P

103.2

ASE

NNAT

chr20:36149606-36152090

1/2

0/0

50

C

P

21.1

NS

  1. ASE, allele-specific expression; CHD, congenital heart disease; FHE, fetal heart expression (reads per million aligned reads); GTEx, Genotype-Tissue Expression Consortium; M, maternal; NE, not expressed; NS, no SNP; P, paternal; SNP, single-nucleotide polymorphism.
  2. *Number subjects with silenced allele/number of informative subjects.
  3. †Mouse ASE observed in pulmonary artery.
  4. ‡PEG10 and RTL1 are not expressed in postnatal cardiac tissues and are silenced in the only fetal subject in the study.
  5. §Mouse ASE observed in skeletal muscle.
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