Figure 6: Rhodopsin dimer models.
From: Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants
(a,d) Cross-sectional view of two distinct dimer interfaces (DI-1 and DI-2) in rhodopsin. The numbered circles correspond to individual helices in the TM helical bundle of each uniquely coloured monomer. (b,c) Top and side views of the interaction interface DI-1 formed by TM1-helix 8 in the opsin crystal structure PDB accession 3CAP. F45 is shown as a CPK model in red. (e,f) Top and side views of the interaction interface DI-2 in which TM5 plays a role. This structural model, obtained by docking the opsin structure (PDB accession 4J4Q) using the HADDOCK webserver, corresponds to cluster-6 in Supplementary Fig. 9. V209 (green) and F220 (gold) are shown as CPK models.
