Figure 4: Broad nAb responses against 25-valent and 50-valent inactivated HRV in RMs.
From: A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
The inactivated-TCID50 input titres per dose are specified in Supplementary Table 3. Two RMs (RM A and RM B) were vaccinated i.m. with 25-valent HRV and alum (a,b), and two RMs (RM C and RM D) were vaccinated i.m. with 50-valent HRV and alum (c,d). nAb titres against input virus types were measured in individual serum samples collected at day 18 (a,c). The RM received an identical boost vaccination at day 28, and sera were collected at day 46 for determining nAb titres post-boost vaccination (b,d). Error bars depict 95% confidence interval. The dashed line represents LOD. Undetectable nAb were assigned LOD/2.
