Figure 2: Advanced aortic root plaques of WD-fed Ldlr−/− mice exhibit an imbalance in 5-LOX-derived SPMs and LTs compared with earlier stage lesions. | Nature Communications

Figure 2: Advanced aortic root plaques of WD-fed Ldlr−/− mice exhibit an imbalance in 5-LOX-derived SPMs and LTs compared with earlier stage lesions.

From: An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

Figure 2

(a) Aortic root lesions from Ldlr−/− mice fed the WD for 8 weeks (Early) or 17 weeks (Advanced) were quantified for necrotic area and mean fluorescence intensity after DHE staining (data are shown as mean±s.e.m., t-test, ***P<0.001, n=7 for early lesions and n=11 for advanced plaques). (b,c) Analysis of lipid mediators in advanced versus early atherosclerotic plaques. Red dots indicate mediators that both reached statistical difference by Student’s t-test (−log10 of the P-value) and changed by at least twofold (log2); blue dots indicate mediators that met only one of these criteria; and black dots represent lipid mediators that met neither of these criteria. For b and c, n=8 for early lesions and n=11 for advanced lesions.

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