Figure 5: Administration of RvD1 to WD-fed Ldlr−/− mice with established atherosclerosis enhances fibrous caps and decreases collagenase and MMP9. | Nature Communications

Figure 5: Administration of RvD1 to WD-fed Ldlr−/− mice with established atherosclerosis enhances fibrous caps and decreases collagenase and MMP9.

From: An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

Figure 5

(a) Representative images and quantification of collagen of 17-week WD-fed Ldlr−/− mice given vehicle control (Veh) or RvD1 for weeks 12–17 (Fig. 3). Scale bar, 100 μm. (b,c) Representative images and quantification of collagenase and MMP9. Scale bar, 100 μm. Data are shown as mean±s.e.m., t-test, **P<0.01 and ***P<0.001, n=11 for Veh group and n=10 for RvD1 group.

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