Table 1 Quantification of DHA-derived lipid mediators in stable and vulnerable regions of human carotid atherosclerotic plaques.

From: An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

Lipid mediator

Stable (pg g −1 (mean±s.e.m.))

Vulnerable (pg g −1 (mean±s.e.m.))

DHA-derived

 4-HDHA

163.9±64.6

831.7±457.3

 7-HDHA

49.2±15.9

144.9±48.0*

 17-HDHA

71.4±10.4

129.5±19.1*

 14-HDHA

303.1±67.2

839.4±280.3*

 PD1

2.3±1.7

2.0±0.6

 Mar1

ND

ND

 RvD1

110.3±15.6

4.2±2.7*

 RvD2

ND

ND

 RvD3

ND

ND

 RvD4

ND

ND

 RvD5

ND

ND

 RvD6

ND

ND

 17R-RvD1

63.4±30.5

93.09±48.2

 22-OH-PD1

ND

ND

 13-HDHA

100.7±17.4

223.8±60.2*

 17R-RvD3

1.8±1.4

0.4±0.1

 4S,14S-diHDHA

ND

ND

 Δ12-trans-MaR1

ND

ND

 7-epi,Δ12-trans-MaR1

2.1±1.0

10.7±2.5*

  1. DHA, docosahexaenoic acid; ND, not detected.
  2. *P<0.05 (paired analysis).
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