Figure 1: 14-3-3ζ deficiency reveals defective arterial thrombosis after electrolytic injury. | Nature Communications

Figure 1: 14-3-3ζ deficiency reveals defective arterial thrombosis after electrolytic injury.

From: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Figure 1

(a–d) Electrolytic injury was induced in the carotid artery of 14-3-3ζ-wt (black symbols/bars) or 14-3-3ζ-deficient (14-3-3ζ-null, white symbols/bars) mice, as described under ‘Methods’. Carotid artery blood flow was monitored for 60 min following arterial injury (injury+stasis) (a), and further analysed offline. Total blood flow (b), time of vessel patency (c) and time to initial occlusion (d) were quantified over a 60 min period. Note: where vessels did not occlude, vessel patency was recorded as 60 min. Results reflect mean±s.e.m. (n=5), with results analysed using an unpaired student t-test (**P<0.01, ***P<0.001). (e) The effect of 14-3-3ζ deficiency on stability of blood flow post injury was classified into three categories, as described under ‘Methods’.

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