Figure 6: In vivo effects of GapmeR targeting lnc-MGC (MGC10) in mice. | Nature Communications

Figure 6: In vivo effects of GapmeR targeting lnc-MGC (MGC10) in mice.

From: An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy

Figure 6

(a) Increase of lnc-MGC in kidney cortex and glomeruli from STZ diabetic mice and its significant inhibition by MGC10 injection. Five mice for NS and STZ groups and six mice for STZ+C and STZ-MGC10 groups. Results are mean+s.e. in triplicate PCRs from each mouse. *P<0.05. (b–f) Increase of miR-379 (b), miR-494 (c), miR-495 (d), miR-377 (e) but not miR-822 (f) in kidney cortex and glomeruli from STZ diabetic mice and their significant inhibition by injection of MGC10. (g,h) Decrease of miR-379 target Edem3 and miR-494 target Atf3 in kidney cortex and glomeruli from STZ diabetic mice and significant restoration of their levels by injection with MGC10. (i–l) Increase of profibrotic genes Col1a2 (i), Ctgf (j), Col4a1 (k) and Tgf-β1 (l) in kidney cortex and glomeruli from STZ diabetic mice and significant inhibition by injection of MGC10. *P<0.05.

Back to article page