Figure 7: Proposed model for the differential regulation of Lhb and Cga through distinct modifications of their promoter chromatin.
From: H2A.Z controls the stability and mobility of nucleosomes to regulate expression of the LH genes
In non-expressing cells, the regulatory regions of both Cga and Lhb, which include binding sites for important TFs, are covered by nucleosomes, and the genes are repressed. In gonadotropes, these genes are remodelled in different ways, tailored to achieve a moderate expression of Lhb and a much higher expression of Cga.
