Figure 4: vWA Ub-binding patch and K84 are exposed in the proteasomal context.
From: Structure of ubiquitylated-Rpn10 provides insight into its autoregulation mechanism
(a) Rpn10 loosely interacts with neighbouring proteasome subunits. (b) The vWA:Ub-binding patch is exposed in the proteasomal context. The proteasome surface is rendered in dark grey; the Ub-binding patch is in yellow. (c) Zoom-in into the non-covalent Ub-binding patch at the proteasome. The side chains of residues participating in Ub binding are rendered as spheres and coloured yellow. (d) Ub bound to the non-covalent Ub-binding patch based on the crystal lattice. Ub residues that participate in binding are also rendered as yellow spheres. (e) Revealing Rpn10-K84 as exposed in the context of the proteasome.
