Figure 6: Pharmacokinetic and biodistribution analysis.
From: Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy
(a) Blood circulation curve of the Cy5.5-labelled BPQDs/PLGA NSs determined by measuring the Cy5.5 fluorescence intensity in the blood of the MCF7 tumour-bearing Balb/c mice at different time points post-injection of the NSs. The pharmacokinetics obeys a typical two compartment model (as shown by the fitted curve). (b) In vivo fluorescence images of the NSs-treated mice at different time points post-injection. (c) Ex vivo fluorescence images of the tumour and major organs from the NSs-treated mice at 24 h post-injection. H, heart; I, intestine; K, kidney; Lu, lung; Li, liver; Sp, spleen; St, stomach; T, tumour. (d) Fluorescence microscopy images of the tumour sections at macro-organizational level (scale bars, 1 mm) and micro-organizational level (scale bars, 50 μm) from the NSs-treated mice. The NSs are shown in red and the nuclei are shown in blue by staining with DAPI. (e) Quantitative biodistribution analysis of the NSs in mice by measuring the Cy5.5 fluorescence intensity in the tumours and major organs at different time points post-injection.
