Figure 2: NLRC4 inflammasome promotes tumour growth in diet-induced obese mice.
From: Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
(a–d) The indicated mice were treated as in Fig. 1. Data represent body weight (a) in Casp1/11−/− mice versus WT mice) or the average Py8119 tumour volume±s.e.m. (b–d; n=5 Casp1/11−/− ND, n=5 Casp1/11−/− HFD, n=5 Nlrp3−/− ND, n=4 Nlrp3−/− HFD, n=5 Nlrc4−/− ND, n=9 Nlrc4−/−- HFD n=14 WT ND, n=24 WT HFD). Two-way ANOVA was used to determine significance. (e) Py8119 tumour volumes 4 weeks after implantation from the indicated mice from a to d. Indicated P values are from a Student's t-test comparing individual group means. One-way ANOVA was performed across all groups: P<0.0001. (f) Average E0771 tumour volume±s.e.m. from the indicated mice (n=5 WT ND, n=5 WT HFD, n=5 Nlrc4−/− ND, n=9 Nlrc4−/− HFD). Two-way ANOVA was used to determine significance. All tumour studies were repeated in a different cohort of animals.
