Figure 7: The association of MAN2C1 with the biochemical recurrence of PTEN-positive prostate cancer.

(a) The percentages of MAN2C1-positive cells in normal prostate glands, as well as in PTEN-positive and -negative PINs and carcinomas, were determined on the basis of the IHC staining of TMA2 and TMA 5. Results were derived from four biological replicates. Means±standard derivations are shown. *P<0.05 (two-tailed Student's t-test) in comparison with PTEN-negative PINs and carcinomas. (b, c) MAN2C1 associates with biochemical recurrence, defined as rising serum levels of prostate-specific antigen (PSA) after radical prostatectomy, in PTEN-positive prostate cancer. Kaplan–Meier analysis of biochemical recurrence-free survival for a subset of PTEN-positive PC patients (b, n=240; log-rank test statistic=18.137, P<0.01) and PTEN-negative PC patients (c, n=153; log-rank test statistic=0.307, P=0.307) with MAN2C1-positive or MAN2C1-negative PC. Data were generated using TMA5. Censored patients in MAN2C1-negative (negative-censored) and MAN2C1-positive (positive-censored) populations are indicated.