Figure 1: Reversible regulation of VEP contralateral bias in adults. | Nature Communications

Figure 1: Reversible regulation of VEP contralateral bias in adults.

From: Recovery from chronic monocular deprivation following reactivation of thalamocortical plasticity by dark exposure

Figure 1

(a) Representative layer IV VEP waveforms evoked by visual stimulation of the contralateral (contra) and ipsilateral (ipsi) eye in adults with binocular vision (control) chronic monocular deprivation (cMD), cMD followed by dark exposure and reverse deprivation (DE-RD; average of 100 presentations of 0.02–0.04 cycles/degree horizontal gratings, 96% contrast, reversing at 1 Hz). Scale bars, 50 ms, 50 μV. (b) Photomontage of nissl stain confirms placement of recording electrode (*) in layer IV of visual cortex. Scale bar, 500 μm. (c) Chronic monocular deprivation induces a significant reduction in VEP contralateral bias (VEP amplitude (amp) in response to stimulation of contralateral eye/ipsilateral eye), which recovers following dark exposure and reverse deprivation (average±s.e.m.; one-way ANOVA, F(2,14)=94.5117, P<0.0001, n=5 each group). (d) Reversible regulation of the deprived eye VEP amplitude (one-way ANOVA, F(2,14)=155.2638, P<0.0001). (e) Reversible regulation of the non-deprived eye VEP amplitude (one-way ANOVA, F(2,14)=114.2875, P<0.0001); *P<0.05 versus control, Tukey–Kramer honestly significant difference post hoc).

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