Figure 4: Parallel regulation of dendritic spine density in all laminae of the deprived visual cortex. | Nature Communications

Figure 4: Parallel regulation of dendritic spine density in all laminae of the deprived visual cortex.

From: Recovery from chronic monocular deprivation following reactivation of thalamocortical plasticity by dark exposure

Figure 4

Chronic monocular deprivation (cMD) induces a significant decrease in dendritic spine density relative to binocular control (Con) in all cortical lamina. The reduction in dendritic spine density is unchanged following dark exposure (DE). Dark exposure and reverse deprivation (DE-RD) induce a significant increase in dendritic spine density in all cortical laminae (average normalized spine density±s.e.m.: one-way ANOVAs: superficial F(3,26)=3.7793, P=0.0243 (Con (7,4), cMD (7,5), DE (8,5), DE-RD (5,4)); mid F(3,22)=6.7756, P=0.0027 (Con (5,4), cMD (7,4), DE (6,4), DE-RD (5,3)); deep F(3,28)=4.5740, P=0.0110, (Con (7,6), cMD (10,5), DE (6,4), DE-RD (6,5)); *P<0.05 versus control, Tukey–Kramer honestly significant difference post hoc; n (neurons, subjects)). Large symbols represent group average, small symbols represent data from individual neurons.

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