Figure 2: Average dopamine release (N=10 rats) during cue and lever epochs for each trial type.
From: Phasic dopamine release in the rat nucleus accumbens predicts approach and avoidance performance
(a) Dopamine release (nM) across time for reward (blue), neutral (yellow), and shock (red) trials. Dopamine release is baseline (5s before light onset to light onset) subtracted. (b–e) Quantification of DA release for press and non-press responses during the cue epoch (cue onset to lever extension; 5s) and lever epoch (lever extension plus 1s). Bars with asterisks represent significance (T-test; P<0.05). Error bars represent s.e.m. (f,g) Correlation between shock and reward trials normalized over neutral trials (shock minus neutral; reward minus neutral) for both cue epoch and lever epoch. (h–m) False-color plots indicate voltammetric current (z-axis) plotted against applied scan potential (y-axis) and time (x-axis) for representative press trials aligned to cue onset for each of the three trial types (h–j; Reward, Neutral, and Shock), as well as averaged press trials aligned to cue onset for each of the three trial types (k–m; Average Reward, Average Neutral, Average Shock). Insets show cyclic voltammogram for dopamine; scale bars are set to 0.7 nA for individual examples and 0.4 nA for averages.
