Figure 3: CSN5 inhibition exhibits a differentiating effect on the viability of cancer cells. | Nature Communications

Figure 3: CSN5 inhibition exhibits a differentiating effect on the viability of cancer cells.

From: Targeted inhibition of the COP9 signalosome for treatment of cancer

Figure 3

(a) Concentration dependent effects of bortezomib (red), CSN5i-2 (green) and CSN5i-2e (blue) on a panel of cancer cell lines. Shown are the high-concentration effect level (Amax) as derived from the sigmoidal fit of the individual dose–response curves and the corresponding transitional concentration values (EC50). (b,c) Individual dose response curves of bortezomib and CSN5i-3-treated cell lines (n=2, ±s.d.).

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