Figure 2: Microiontophoretic drug application and cell-type classification. | Nature Communications

Figure 2: Microiontophoretic drug application and cell-type classification.

From: Cell-type-specific modulation of targets and distractors by dopamine D1 receptors in primate prefrontal cortex

Figure 2

(a) Top: schematic of a rhesus monkey brain depicting the location of simultaneous single-unit recordings and multi-pipette iontophoretic drug application in the lateral PFC. Bottom: anatomical surface reconstruction of the recording sites in monkey R and W (left and right, respectively). (b) Schematic of iontophoretic drug application to the local microcircuit consisting of excitatory pyramidal neurons and inhibitory interneurons. (c) Spike waveforms for all analysed sample-selective neurons (P<0.01 in any task epoch) that were successfully classified as broad-spiking (BS) or narrow-spiking (NS). Cluster centroids for each class are marked in black. (d) Distribution of spike widths for the neurons in c. (e) Firing rates for the neurons in c averaged within each task epoch in control conditions, with D1R inhibition (SCH23390) and D1R stimulation (SKF38393).

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