Figure 8: Phylogenetic tree of members of the Poxviral Immune Evasion (PIE) superfamily with known structures. | Nature Communications

Figure 8: Phylogenetic tree of members of the Poxviral Immune Evasion (PIE) superfamily with known structures.

From: Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Figure 8

The phylogenetic tree, based on the alignment presented in Supplementary Fig. 1, is generated by ClustalW2 (ref. 78) and visualized by Geneious 4.8.5 (ref. 79). The scale bar represents the number of substitutions per site. Representative structures (Orf virus GIF: 5D28, Orf virus CKBP: 4ZK9 , Vaccinia virus A41: 2VGA, Rabbitpox virus vCCI: 2FFK, ectromelia virus SECRET domain: 3ON9 , Rabbitpox virus CPXV203: 4HKJ) displaying a variation of the PIE superfamily β-sandwich fold are shown for each branch.

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