Table 1 Study population.
From: A novel methodology for large-scale phylogeny partition
Variables | n | % | ||
|---|---|---|---|---|
Sequences | 11,541 | 100 | ||
Patients | 7,350 | 63.69 | ||
Patients with known seroconversion date | 258 | 3.51 | ||
Patients with known date of first HIV-1 positive test | 2,720 | 37.01 | ||
Country area | ||||
Central Italy | 3,274 | 44.54 | ||
Northern Italy | 3,528 | 48.00 | ||
Southern Italy | 443 | 6.03 | ||
Unknown | 105 | 1.43 | ||
Mode of HIV-1 transmission | ||||
Injecting drug user | 1,418 | 19.29 | ||
Heterosexual | 1,439 | 19.58 | ||
Male homosexual | 1,313 | 17.86 | ||
Other/unknown | 3,180 | 43.27 | ||
Gender | ||||
Female | 1,677 | 22.82 | ||
Male | 5,111 | 69.54 | ||
Unknown | 562 | 7.65 | ||
Country of birth | ||||
Italy | 4,210 | 57.28 | ||
Other countries | 229 | 3.12 | ||
Unknown | 2,911 | 39.60 | ||
All sequences (number of patients) | ||||
ART-naive | 1,287 (1,116) | 11.15 (15.18) | ||
ART-experienced | 6,962 (3,603) | 60.32 (49.02) | ||
Unknown ART status | 3,292 (2,631) | 28.52 (35.80) | ||
Presence of at least one resistance mutation for a specific drug class (one sequence per patient) | Considering mixtures of resistant mutants and wild types at specific positions | Not considering mixtures of resistant mutants and wild types at specific positions | ||
Any class | ||||
ART-naive | 246 | 22.04% | 164 | 14.69% |
ART-experienced | 2,911 | 80.79% | 2,657 | 73.74% |
NRTI | ||||
ART-naive | 125 | 11.20% | 109 | 9.77% |
ART-experienced | 2,712 | 75.27% | 2,512 | 69.72% |
NNRTI | ||||
ART-naive | 145 | 12.99% | 76 | 6.81% |
ART-experienced | 1,485 | 41.21% | 1,147 | 31.83% |
PI | ||||
ART-naive | 69 | 6.18% | 55 | 4.93% |
ART-experienced | 1,312 | 36.41% | 1,135 | 31.50% |
Numerical markers | Median | IQR | ||
Sequence year | 2004 | 2002–2007 | ||
Number of sequences per patient | 1 | 1–2 | ||
HIV-1 RNA Log 10 copies per ml | ||||
ART-naive | 4.64 | 4.04–5.23 | ||
ART-experienced | 3.98 | 3.32–4.65 | ||
CD4+ T cells per mm 3 | ||||
ART-naive | 361 | 196–556 | ||
ART-experienced | 334 | 191–504 | ||
Age (years) | ||||
ART-naive | 37 | 31–44 | ||
ART-experienced | 41 | 37–46 | ||
Time passed from the first HIV+ test (years) | ||||
ART-naive | 0 | 0–1 | ||
ART-experienced | 10 | 6–15 | ||
