Figure 4: Phosphoproteomics data elucidate the relationships between different drugs. | Nature Communications

Figure 4: Phosphoproteomics data elucidate the relationships between different drugs.

From: Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion

Figure 4

(a) Principal component analysis (PCA) of Min6 beta cells treated with different drugs reveals three clusters. Negative controls cluster together and are separated from drug treated cells. (b) Loadings of A reveal that the phosphosites responsible for driving the segregation in component 1 and 2 are significantly enriched in (c) specific kinase substrate motifs (FDR<0.05). (d) Unsupervised, hierarchical clustering (Pearson correlation distance) of the log2 intensity of 22,241 phosphorylation sites. (e) Heat map of phosphorylation levels of the indicated phosphosites upon drug and glucose treatments. (f) Schematic representation of the effects of drug treatments in beta cells.

Back to article page