Figure 7: The DNMT3A phosphorylation of S7 affects the gene expression profile of beta cells. | Nature Communications

Figure 7: The DNMT3A phosphorylation of S7 affects the gene expression profile of beta cells.

From: Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion

Figure 7

(a) Volcano plot of MS-quantified wild-type DNMT3A interactors in glucose treated or starved Ins1e cells. (b) Significant interactors of DNMT3A. Volcano plot of MS-quantified proteins in wild type and S7A mutant in glucose treated Ins1e cells. (c) Volcano plot of MS-quantified proteins after the overexpression of the wild type form of DNMT3A or empty vector as control, in Ins1e cells. (d) Scatterplot of proteins significantly downregulated after the overexpression of wild type or S7A mutant forms of DNMT3A in Ins1e cells. (e) Scatterplot of significantly downregulated proteins after the overexpression of wild-type form of DNMT3A and stimulation with glucose (16.7 mM) for 6 h in Ins1e cells. (f) Schematic representation of the proposed model. (g) Bar graph representing GO-Biological processes enriched in the proteins that are downregulated by both glucose and DNMT3A overexpression.

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