Figure 2: Orientation changes of the E-helix probe in response to a force step in relaxed muscle. | Nature Communications

Figure 2: Orientation changes of the E-helix probe in response to a force step in relaxed muscle.

From: Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle

Figure 2

Upper panel: force (bar length=110 pN per thick filament); middle panels: fibre length change (ΔL) relative to initial fibre length (L0) and sarcomere length change (ΔSL) relative to initial sarcomere length (SL0=2.8 μm); lower panel: <P2> for the E-helix probe. Black: 25 °C, 5% Dextran; green: 25 °C, 5% Dextran, 25 μM Blebbistatin; magenta: 8 °C, no Dextran or Blebbistatin. Red: single-exponential fits following force increase (black: 256 s−1, green: 270 s−1) and decrease (black: 313 s−1, green: 367 s−1).

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