Figure 6: SRS imaging of non-SOD1 mouse models demonstrated the general utility in studying ALS.
From: Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging
(a) Disease progression of AAV-C9ORF72 repeat expansion over-expression mouse model of ALS. (b) Representative SRS images of AAV-C9ORF72 mouse model of ALS showing healthy nerve fiber morphology for 2 repeats (2R) and lipid ovoid deposition (66R). Scale bar, 50 μm. (c) Lipid ovoid quantification result of AA-C9ORF72 mouse model of ALS. Data are presented as mean±s.e.m., and error bars show s.e.m. (d) Disease-related phenotype progression in FUSP525L mouse ALS model. (e) FUSP525L versus FUS WT ex vivo SRS images at 12 weeks of age. Scale bar, 50 μm. (f) Quantification of lipid ovoids and statistical significance analysis for FUSP525L mouse model of ALS. Data are presented as mean±s.e.m., and error bars show s.e.m.
