Figure 7: Lipid ovoid deposition could result from initial axon degeneration.
From: Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging
(a) Experimental design of SRS imaging for sciatic nerve crush model. (b) Lipid ovoid quantification result of sciatic nerve crush experiment. *P<0.05. N=4 for each strain or each age point. Data are presented as mean±s.e.m., and error bars show s.e.m. (c,d) Sciatic nerve SRS images of WT mice after crush and recovery. Scale bar, 50 μm. (e) MS like phenotypes and disease progression of EAE model. (f) Sciatic nerve SRS images of EAE model. The left arrow shows demyelination morphology, and the right arrow shows remyelination morphology. Scale bar, 50 μm. (g) Lipid ovoid quantification result of EAE model SRS imaging.
