Figure 3: Vasculogenic mimicry in SCLC CDX tumours. | Nature Communications

Figure 3: Vasculogenic mimicry in SCLC CDX tumours.

From: Vasculogenic mimicry in small cell lung cancer

Figure 3

(a). IHC of CK and SCLC neuroendocrine markers CD56, synaptophysin and chromogranin of a matched patient biopsy and CDX tumour. Scale bar, 50 μm. (b) Mean evaluable tumour area (mm2) in sections from n=24 patient bronchoscopic biopsies and n=10 CDX tumours (***P<0.0001, two-tailed t-test. (c) Left panel depicts PAS+VE/CD31+VE endothelial vessels (black arrow) and PAS+VE/CD31−VE VM vessels (red arrow) in a representative SCLC CDX tumour. Right panel depicts Masson trichrome staining of the same region demonstrating lack of mouse stromal contamination. Scale bar, 50 μm. (d) VM vessels per mm2 of tissue in CDX tumours derived from CTCs enriched from SCLC patients (P denotes a CDX tumour derived from a progression blood sample matched to a baseline patient sample, for example, CDX3 and CDX3P are both derived from patient 3 at presentation and progression, respectively). Error bars show s.e.m.

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