Figure 9: Efficacy of cisplatin-etoposide treatment in H446 and H446 VE-cadherin KD xenografts.

(a) Tumour response measured post randomization as a percentage tumour volume change relative to size at randomization (n=10 tumour-bearing animals per group). (b) Univariate survival analysis following cisplatin/etoposide treatment in H446 parental and H446 VE-cadherin KD xenografts. Kaplan–Meier survival analysis for tumours treated with vehicle or cisplatin/etoposide (n=10 animals per group (ns=non-significant, *P=0.03, ***P=0.0003, Mantel–Cox test)).