Table 1 Clinical and genetic features of patients with MEF2D-rearranged ALL.
From: Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
Sample ID | Fusion | Age | WBC | Sex | Karyotype | SNP results |
|---|---|---|---|---|---|---|
SJBALL013388 | MEF2D-BCL9 a | 10.0 | 45.4 | Female | NA | NA |
SJBALL016252 | MEF2D-BCL9 a | 14.0 | 42 | Female | NA | NA |
SJBALL016291 | MEF2D-BCL9 a | 10.0 | 23 | Male | NA | NA |
SJBALL020667 | MEF2D-BCL9 a | 14.8 | 39 | Female | NA | No MEF2D change |
SJBALL020703 | MEF2D-BCL9 a | 14.2 | 38 | Female | 46,XX,del(9)(p22)x2[10]/45,idem,−del(9),+der(9;17)(q10;q10),−17[6]/46,idem,−del(9),+mar[4] | No MEF2D change |
SJBALL020711 | MEF2D-BCL9 b | 13.9 | 96.4 | Male | NA | Focal gains at MEF2D and BCL9 |
SJBALL020906 | MEF2D-BCL9 b | 15.1 | 9.1 | Male | NA | Deletion between BCL9 and MEF2D |
SJCOGALL010235 | MEF2D-BCL9 a | 13.5 | 82.7 | Female | 46,XX,dup(1)(q24q31),i(7)(q10),del(9)(p21p24),add(18)(q21)[8]/46,XX,dup(1)(q24q31),add(9)(p22),del(9)(p21p24),del(10)(p13p14)[7]/46,XX[4] | NA |
SJBALL014169 | MEF2D-BCL9 b | 21.3 | 20.9 | Female | 46,XX,del(12)(p11.2)[2]/45,XX,−9,del(12)(p11.2)[15] /45,XX,−11[1] | NA |
SJBALL020917 | MEF2D-HNRNPUL1 | 11.9 | 3.5 | Female | 46,XX,del(13)(q12q32)[24]/46,XX[6] | Focal gains at MEF2D and HNRNPUL1 |
SJBALL020967 | MEF2D-BCL9 b | 16.3 | 27 | Female | 46,X,t(X;6;15)(q22;p21;q13),−2,add(9)(p13),del(9)(p13p22),der(?)t(?;2)(?;q13)[4]/89,idemx2,−7,−del(9),−11[5]/46,XX[11] | Focal gains at MEF2D and BCL9 |
SJBALL020964 | MEF2D-HNRNPUL1 | 17.6 | 10.8 | Male | 46,XY,dup(2)(q31q33),del(12)(p11.2)[22] | Focal gain at HNRNPUL1 |
SJBALL016275 | MEF2D-BCL9 c | 15.0 | 61.9 | Male | NA | NA |
SJBALL016306 | MEF2D-BCL9 c | 12.0 | 61.9 | Female | NA | NA |
SJCOGALL010915 | MEF2D-BCL9 c | 14.0 | 7.4 | Male | 48,XY,add(3)(q11.2),+8,del(8)(p11.1),add(12)(p11.2),+mar[11]/94,idemx2,−8,−8,−21,+mar[6]/46,XY[2] | NA |
SJCOGALL010884 | MEF2D-BCL9 d | 13.8 | 107 | Female | 46,XX,add(9)(p13)[1]/46,idem,dup(1)(q12q42)[5]/46,XX[14] | NA |
SJBALL020987 | MEF2D-BCL9 a | 18.5 | 22.5 | Female | 46,XX,del(9)(p13),t(10;14)(q23;q11.2)[17]/46,XX[1] | No MEF2D change |
SJBALL021005 | MEF2D-BCL9 a | 17.6 | 9.4 | Male | NA | Deletion at MEF2D, and adjacent gain to BCL9 |
SJCOGALL010859 | MEF2D-HNRNPUL1 | 7.6 | 21.8 | Female | 46,XX,add(7)(q11.2),add(9)(p13)[8]/46,XX[5] | NA |
SJBALL016286 | MEF2D-SS18 | 9.0 | 28.1 | Female | NA | NA |
SJBALL020141 | MEF2D-DAZAP1 * | 35.0 | 5.4 | Male | NA | Gain from MEF2D to 1cent; Gain from 19p to DAZAP1 |
SJBALL015117 | MEF2D-CSF1R † | 48.0 | Female | NA | NA |
