Figure 7: Pathological implications of elevated HCys levels. | Nature Communications

Figure 7: Pathological implications of elevated HCys levels.

From: Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases

Figure 7

In some forms of cancer and some neurodegenerative diseases, disturbed HCys levels, in combination with perturbed homeostasis of redox-active transition metal ions, can lead to sulfheme formation without H2S intervention. Sulfheme formation occurs through the unprecedented S-oxygenation of HCys by the heme-oxo-iron(IV) of catalase. The resulting prosthetic heme modification induces an irreversible inhibition of catalase bioactivity and may participate to the aetiology of various disorders.

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