Table 2 Summary of catalase inactivation parameters in the presence or absence of various additives*.

From: Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases

Additives

Activity test

k inact , min −1

Ultraviolet–visible spectroscopy

k obs (6), min −1

k obs (11) × 10 3 , min −1

None

0.029±0.002

0.026±0.003

7.88±0.62

DMPO

0.009±0.001

0.010±0.002

5.33±0.29

SOD

0.018±0.001

0.020±0.002

6.73±0.39

Dimedone

†0.018±0.002

†0.019±0.003

4.17±0.23

BCN

ND

0.018±0.002

4.39±0.11

  1. *The ultraviolet–visible spectroscopy experiments (n≥2±s.d.) and the activity tests (n=2±s.d.) were performed as described in ‘Methods’ section.
  2. †Effect due to the reactivity of dimedone with H2O2 and O2·−(see Supplementary Fig. 12).ND, not determined.
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