Figure 8: Model of hematopoietic reprogramming.
From: Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors
Scl, Lmo2, Runx1 might act as ‘lineage commitment’ regulators whereas Bmi1 or Hoxb4 might be ‘self-renewal’ factors in HSC development. The hematopoietic reprograming activity of these transcription factors also jointly requires extracellular signals mediated through the BMP and MEK cascades. Finally, Lmo2 activates other hematopoietic transcription factors (for example, Gfi1 and Hhex) to drive iHP reprogramming.
