Figure 4: Synthesis of N-terminal heptapeptide 3 using micro-flow amidation.

Conditions: (a) Pd(PPh3)4, PhSiH3, CH2Cl2/MeOH/H2O, r.t., 40 min, batch. (b) PS-Ph3P-Pd, PhSiH3, CH2Cl2/MeOH/H2O, r.t., 1.5–2.5 h, batch.
Conditions: (a) Pd(PPh3)4, PhSiH3, CH2Cl2/MeOH/H2O, r.t., 40 min, batch. (b) PS-Ph3P-Pd, PhSiH3, CH2Cl2/MeOH/H2O, r.t., 1.5–2.5 h, batch.