Figure 2: Detailed characterization of the VMP1/microRNA-21 region. | Nature Communications

Figure 2: Detailed characterization of the VMP1/microRNA-21 region.

From: Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Figure 2

(a) VMP1/microRNA-21 region 450 K microarray probes (triangle) in inflammatory bowel disease cases (IBD, Red) and controls (Blue). (b) the same VMP1/microRNA-21 region mapped using whole genome bisulphite sequencing (WGBS) data (Red line=IBD cases, Blue line=Controls). (c) VMP1/microRNA-21 gene schematic diagram. Note only the first two exons of VMP1 shown. (d) Correlation between 450k microarray probes and WGBS data at same site. Correlation using Pearson’s test. X axis denotes Chr 17 (h19) coordinates. DMR, differentially methylated region in IBD versus control case control 450k analysis.

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