Figure 4: VMP1 genotype associates with DNA methylation. | Nature Communications

Figure 4: VMP1 genotype associates with DNA methylation.

From: Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Figure 4

(a) The genotype of rs8078424 strongly associates with VMP1 DNA methylation (cg16936953) (FDR corrected P=8.8 × 10−5, linear model). (b) VMP1 DNA methylation strongly associates with Inflammatory bowel disease (IBD) case status compared with controls (Holm corrected P=2.2 × 10−13, linear model). (c) The rs8078424 genotype associates with IBD status (Cochran-Armitage test 1df χ2=4.7 uncorrected P=0.03)(rs10853015 also associates Cochran-Armitage test 1df χ2=6.6 uncorrected P=0.01, both in Hardy-Weinberg equilibrium). Error bars denote s.e. (d) The two SNPs (rs10853015 and rs8078424, blue diamonds) that associate with methylation of the VMP1/microRNA-21 locus (red inverted triangle) are in linkage disequilibrium with the known IBD-susceptibility polymorphism (rs1292053, green diamond)(rs1292053-rs8078424, distance=13072, bp, D′=1, r2=0.43 and rs1292053–rs10853015, distance=185198, D′=0.93, r2=0.43). Plot generated using SNAP69.

Back to article page