Table 1 Top table of differentially methylated positions (DMPs) between inflammatory bowel disease (IBD) cases and controls in whole blood.

From: Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Illumina 450K probe ID

Chr

Gene symbol

Feature

Relation to UCSC CpG island

Δβ

P value

Holm adj. P value

cg17501210

chr6

RPS6KA2

Body

 

−0.08

2.71E−22

1.22E−16

cg18608055

chr19

SBNO2

Body

 

−0.07

2.02E−20

4.53E−15

cg16936953

chr17

VMP1

Body

 

−0.09

1.33E−19

1.99E−14

cg09349128

chr22

NA

IGR

N_Shore

−0.04

3.11E−19

3.48E−14

cg25114611

chr6

NA

TSS1500

S_Shore

−0.04

1.10E−18

8.79E−14

cg12170787

chr19

SBNO2

Body

 

−0.04

1.18E−18

8.79E−14

cg12992827

chr3

NA

IGR

 

−0.06

6.26E−18

4.01E−13

cg19821297

chr19

NA

IGR

S_Shore

−0.06

3.66E−17

1.98E−12

cg12054453

chr17

VMP1

Body

 

−0.07

3.98E−17

1.98E−12

cg01059398

chr3

TNFSF10

Body

 

−0.05

1.59E−16

7.13E−12

cg26470501

chr19

BCL3

Body

S_Shore

−0.03

5.79E−16

2.29E−11

cg07398517

chr3

NA

IGR

 

−0.04

6.14E−16

2.29E−11

cg26804423

chr7

ICA1

Body

 

0.04

6.84E−16

2.36E−11

cg18942579

chr17

VMP1

Body

 

−0.05

1.17E−15

3.74E−11

  1. Adj., adjusted; Chr, chromosome; IGR, intergenic region, TSS1500, within 1,500 bp of a transcription start site.
  2. Δβ, difference in beta values (ratio of methylated and total probe intensity (0 to 1) between IBD cases and controls, positive value indicated increased methylation in cases compared to controls, negative values indicated hypomethylation in IBD cases versus controls. NA denotes methylation probes with no annotated gene symbol. P values are derived from linear models including age, sex and cell proportions as covariates.
Back to article page