Table 2 List of differentially methylated regions (DMRs) between inflammatory bowel disease (IBD) cases and controls in whole blood.

From: Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Gene

Feature

Chr

Δβ

Min Holm adj. P value

DMR size

Probe counts

Disease

VMP1

Body

17

−0.09

5.96E−14

1150

4

IBD, CD, UC

WDR8

Body

1

0.03

9.76E−08

1943

3

IBD, CD, UC

NA

IGR

1

0.04

1.83E−07

1997

3

IBD

ITGB2

5′-UTR

21

0.04

3.28E−05

623

3

IBD, CD

TXK

5′-UTR

4

0.02

0.00014

538

3

IBD

  1. Adj., adjusted; CD, Crohn’s disease; Chr, chromosome; UC, ulcerative colitis.
  2. Where a single P value or beta difference is presented, this represents the corresponding values from the most significant probe within the DMR on differential methylated position analysis (see Table 1). Δβ, difference in beta values (ratio of methylated and total probe intensity (0 to 1) between IBD cases and controls, positive value indicated increased methylation in cases compared with controls, negative values indicated hypomethylation in IBD cases versus controls. NA denotes methylation probes with no annotated gene symbol.
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