Figure 2: Dutch/Iowa CAA mutant cerebral microvascular amyloid in Tg-SwDI mice promotes the accumulation of administered biotin-labelled wild-type Aβ peptides. | Nature Communications

Figure 2: Dutch/Iowa CAA mutant cerebral microvascular amyloid in Tg-SwDI mice promotes the accumulation of administered biotin-labelled wild-type Aβ peptides.

From: Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure

Figure 2

Biotin-labelled wild-type Aβ40 (a–c) or biotin-labelled wild-type Aβ42 (d–f) were injected into the hippocampal region of 12-month-old Tg-SwDI mice. Brain sections were prepared and fibrillar amyloid was detected using Amylo-Glo (blue) and immunolabelled with an antibody to collagen IV for detection of cerebral blood vessels (red). Biotin-labelled wild-type Aβ40 or Aβ42 peptides were detected using streptavidin-Alexa Fluor 488 (green). Scale bars, 50 μm.

Back to article page