Figure 3: Progressive accumulation of Aβ in transgenic mouse brains.

Representative images of 6–18-month-old transgenic mouse brain sections were immunostained for Aβ (brown) as described in Methods. (a–d) Tg-SwDI mice; (e–h) Tg2576 mice; and (i–l) bigenic Tg-SwDI/Tg2576 mice. High-magnification images show vascular deposits (white arrows) and parenchymal plaques (black arrows). Scale bars: low mag, 1 mm; high mag, 50 μm.