Figure 6: Quantitative immunohistochemical analysis of cerebral human wild-type Aβ deposition in the different transgenic mice. | Nature Communications

Figure 6: Quantitative immunohistochemical analysis of cerebral human wild-type Aβ deposition in the different transgenic mice.

From: Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure

Figure 6

Brain sections obtained from the different transgenic mouse lines at eighteen months of age were double immunolabelled for human Aβ using a polyclonal anti-Aβ (pAb-Aβ) antibody which recognizes both wild-type and CAA mutant Aβ, (green) (a–d) and mAb4G8, which recognizes wild-type Aβ, but not CAA mutant Aβ, (red) (e–h) and images were merged (i–l). Scale bars, 50 μm. (m) The levels of pAb-Aβ-positive total Aβ (green) and mAb4G8-positive wild-type Aβ (red) in parenchymal plaque and capillary deposits were determined in the different transgenic lines. The data presented are the mean±s.d. of 15 deposits per each line of mice.

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