Figure 4: Protein–protein interaction networks show connectivity within and among different phenotypic clusters.
From: Defining functional interactions during biogenesis of epithelial junctions
(a) Hierarchical clustering of actin functions and phenotypic clusters. The enrichment of actin functions in specific clusters (as in Fig. 3e) is shown as a heat map. Protein functions are shown on the right and cluster number and phenotype are shown on the top. Analysis shows similarities among clusters containing specific profiles of functions along the grouping of functions controlling filament organization (top group on the right), intracellular trafficking (middle group on the right) or filament length (bottom group on the right). (b–e) Protein–protein interaction networks of unconventional myosins enriched in Cluster 2 (b), intracellular trafficking proteins in Cluster 3 (c), actin polymerization proteins found in Clusters 1 and 5 networks (d) or capping proteins present in Clusters 3 and 5 interaction maps (e). Clusters are colour-coded as shown in the colour key diagram. Grey circles represent proteins found in available PPI datasets.
