Figure 1: Genetic mapping and epigenetic landscape at the 7p15.3 locus. | Nature Communications

Figure 1: Genetic mapping and epigenetic landscape at the 7p15.3 locus.

From: Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression

Figure 1

Manhattan plot of 7p15.3 is shown with genotyped (triangles) and imputed (circles) SNPs. −log10 P values (y axis) of the SNPs are shown according to their chromosomal positions (x axis; NCBI build 37 of the human genome). The top genotyped SNP (rs4487645) is labelled with a large triangle. The colour intensity of each symbol in the Manhattan plot reflects the extent of linkage disequilibrium with rs4487645, from white (r2=0) to dark red (r2=1.0). Genetic recombination rates are estimated using HapMap Utah residents of Western and Northern European ancestry (CEU) samples, and shown with a light blue line. The relative positions of DNAH11 and CDCA7L transcripts mapping to 7p15.3 are shown. The chromatin state of the DNAH11–CDCA7L gene locus in GM12878 is detailed with H3K4Me1, H3K4Me3, H3K27Ac, FAIRE, DNaseI HS studies and chromatin state segmentation track (ChromHMM), with called peaks on two replicates of IRF4 ChIP-seq in GM12878 shown below accessed from the UCSC Genome Browser. Position of rs4487645 is highlighted with grey line.

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